Enantioselective Synthesis of α-Quaternary Mannich Adducts by Palladium-Catalyzed Allylic Alkylation: Total Synthesis of (+)-Sibirinine

[Image: see text] A catalytic enantioselective method for the synthesis of α-quaternary Mannich-type products is reported. The two-step sequence of (1) Mannich reaction followed by (2) decarboxylative enantioselective allylic alkylation serves as a novel strategy to in effect access asymmetric Manni...

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Detalles Bibliográficos
Autores principales: Numajiri, Yoshitaka, Pritchett, Beau P., Chiyoda, Koji, Stoltz, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311947/
https://www.ncbi.nlm.nih.gov/pubmed/25578104
http://dx.doi.org/10.1021/ja512124c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311947/
https://www.ncbi.nlm.nih.gov/pubmed/25578104
http://dx.doi.org/10.1021/ja512124c

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