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Enantioselective Synthesis of α-Quaternary Mannich Adducts by Palladium-Catalyzed Allylic Alkylation: Total Synthesis of (+)-Sibirinine
[Image: see text] A catalytic enantioselective method for the synthesis of α-quaternary Mannich-type products is reported. The two-step sequence of (1) Mannich reaction followed by (2) decarboxylative enantioselective allylic alkylation serves as a novel strategy to in effect access asymmetric Manni...
Autores principales: | Numajiri, Yoshitaka, Pritchett, Beau P., Chiyoda, Koji, Stoltz, Brian M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2015
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311947/ https://www.ncbi.nlm.nih.gov/pubmed/25578104 http://dx.doi.org/10.1021/ja512124c |
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