Inhibition of EGFR or IGF-1R signaling enhances radiation response in head and neck cancer models but concurrent inhibition has no added benefit

Interaction between the epidermal growth factor receptor (EGFR) and the insulin-like growth factor receptor (IGF-1R) has been well established in many cancer types. We investigated the effects of cetuximab (EGFR antibody) and IMC-A12 (IGF-1R antibody) on the response of head and neck squamous cell c...

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Detalles Bibliográficos
Autores principales: Raju, Uma, Molkentine, David P, Valdecanas, David R, Deorukhkar, Amit, Mason, Kathryn A, Buchholz, Thomas A, Meyn, Raymond E, Ang, Kie-Kian, Skinner, Heath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312119/
https://www.ncbi.nlm.nih.gov/pubmed/25355701
http://dx.doi.org/10.1002/cam4.345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312119/
https://www.ncbi.nlm.nih.gov/pubmed/25355701
http://dx.doi.org/10.1002/cam4.345

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