Uncovering the Polymerase-induced Cytotoxicty of an Oxidized Nucleotide

Oxidative stress promotes genomic instability and human diseases(1). A common oxidized nucleoside is 8-oxo-7,8-dihydro-2’-deoxyguanosine found both in DNA (8-oxo-G) and as a free nucleotide (8-oxo-dGTP)(2,3). Nucleotide pools are especially vulnerable to oxidative damage(4). Therefore cells encode a...

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Detalles Bibliográficos
Autores principales: Freudenthal, Bret D., Beard, William A., Perera, Lalith, Shock, David D., Kim, Taejin, Schlick, Tamar, Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312183/
https://www.ncbi.nlm.nih.gov/pubmed/25409153
http://dx.doi.org/10.1038/nature13886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312183/
https://www.ncbi.nlm.nih.gov/pubmed/25409153
http://dx.doi.org/10.1038/nature13886

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