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Impacts of low coverage depths and post-mortem DNA damage on variant calling: a simulation study
BACKGROUND: Massively parallel sequencing platforms, featuring high throughput and relatively short read lengths, are well suited to ancient DNA (aDNA) studies. Variant identification from short-read alignment could be hindered, however, by low DNA concentrations common to historic samples, which co...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312461/ https://www.ncbi.nlm.nih.gov/pubmed/25613391 http://dx.doi.org/10.1186/s12864-015-1219-8 |