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Myosin-II controls cellular branching morphogenesis and migration in 3D by minimizing cell surface curvature

In many cases cell function is intimately linked to cell shape control. We utilized endothelial cell branching morphogenesis as a model to understand the role of myosin-II in shape control of invasive cells migrating in 3D collagen gels. We applied principles of differential geometry and mathematica...

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Detalles Bibliográficos
Autores principales: Elliott, Hunter, Fischer, Robert A., Myers, Kenneth A., Desai, Ravi A., Gao, Lin, Chen, Christopher S., Adelstein, Robert, Waterman, Clare M., Danuser, Gaudenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312523/
https://www.ncbi.nlm.nih.gov/pubmed/25621949
http://dx.doi.org/10.1038/ncb3092