N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder, involving psychiatric, cognitive and motor symptoms, caused by a CAG-repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. Oxidative stress and excitotoxicity have previously been implicated in the pathoge...

Descripción completa

Detalles Bibliográficos
Autores principales: Wright, D J, Renoir, T, Smith, Z M, Frazier, A E, Francis, P S, Thorburn, D R, McGee, S L, Hannan, A J, Gray, L J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312826/
https://www.ncbi.nlm.nih.gov/pubmed/25562842
http://dx.doi.org/10.1038/tp.2014.131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312826/
https://www.ncbi.nlm.nih.gov/pubmed/25562842
http://dx.doi.org/10.1038/tp.2014.131

Ejemplares similares