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N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder, involving psychiatric, cognitive and motor symptoms, caused by a CAG-repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. Oxidative stress and excitotoxicity have previously been implicated in the pathoge...

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Detalles Bibliográficos
Autores principales:	Wright, D J, Renoir, T, Smith, Z M, Frazier, A E, Francis, P S, Thorburn, D R, McGee, S L, Hannan, A J, Gray, L J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312826/ https://www.ncbi.nlm.nih.gov/pubmed/25562842 http://dx.doi.org/10.1038/tp.2014.131

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