Failed Degradation of JunB Contributes to Overproduction of Type I Collagen and Development of Dermal Fibrosis in Patients With Systemic Sclerosis

OBJECTIVE: The excessive deposition of extracellular matrix, including type I collagen, is a key aspect in the pathogenesis of connective tissue diseases such as systemic sclerosis (SSc; scleroderma). To further our understanding of the mechanisms governing the dysregulation of type I collagen produ...

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Detalles Bibliográficos
Autores principales: Ponticos, Markella, Papaioannou, Ioannis, Xu, Shiwen, Holmes, Alan M, Khan, Korsa, Denton, Christopher P, Bou-Gharios, George, Abraham, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Systemic Sclerosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312903/
https://www.ncbi.nlm.nih.gov/pubmed/25303440
http://dx.doi.org/10.1002/art.38897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312903/
https://www.ncbi.nlm.nih.gov/pubmed/25303440
http://dx.doi.org/10.1002/art.38897

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