Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease

Abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. Glycogen synthase kinase 3β (GSK-3β) is a primary tau kinase that is most implicated in tau pathology in AD. However, the exact molecular nature of GSK-3β involved...

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Detalles Bibliográficos
Autores principales: Jin, Nana, Yin, Xiaomin, Yu, Dian, Cao, Maohong, Gong, Cheng-Xin, Iqbal, Khalid, Ding, Fei, Gu, Xiaosong, Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313118/
https://www.ncbi.nlm.nih.gov/pubmed/25641096
http://dx.doi.org/10.1038/srep08187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313118/
https://www.ncbi.nlm.nih.gov/pubmed/25641096
http://dx.doi.org/10.1038/srep08187

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