The Early Induction of Suppressor of Cytokine Signaling 1 and the Downregulation of Toll-like Receptors 7 and 9 Induce Tolerance in Costimulated Macrophages

Toll-like receptors (TLR) 7 and 9 transduce a cellular signal through the MyD88-dependent pathway and induce the production of inflammatory mediators against microbial nucleotide components. The repeated stimulation of TLR4 leads to endotoxin tolerance, but the molecular mechanisms of tolerance indu...

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Detalles Bibliográficos
Autores principales: Lee, Hyo-Ji, Kim, Keun-Cheol, Han, Jeong A, Choi, Sun Shim, Jung, Yu-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314129/
https://www.ncbi.nlm.nih.gov/pubmed/25518931
http://dx.doi.org/10.14348/molcells.2015.2136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314129/
https://www.ncbi.nlm.nih.gov/pubmed/25518931
http://dx.doi.org/10.14348/molcells.2015.2136

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