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The Early Induction of Suppressor of Cytokine Signaling 1 and the Downregulation of Toll-like Receptors 7 and 9 Induce Tolerance in Costimulated Macrophages

Toll-like receptors (TLR) 7 and 9 transduce a cellular signal through the MyD88-dependent pathway and induce the production of inflammatory mediators against microbial nucleotide components. The repeated stimulation of TLR4 leads to endotoxin tolerance, but the molecular mechanisms of tolerance indu...

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Detalles Bibliográficos
Autores principales:	Lee, Hyo-Ji, Kim, Keun-Cheol, Han, Jeong A, Choi, Sun Shim, Jung, Yu-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314129/ https://www.ncbi.nlm.nih.gov/pubmed/25518931 http://dx.doi.org/10.14348/molcells.2015.2136

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