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Glucose-regulated insulin production in the liver improves glycemic control in type 1 diabetic mice()

OBJECTIVE: Type 1 diabetes results from autoimmune destruction of beta-cells in the pancreas. Our objective is to reconstitute a glucose-responsive system in the liver to regulate hepatic insulin production for improving glycemic control in type 1 diabetes. METHODS: We have cloned the glucose-respon...

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Detalles Bibliográficos
Autores principales: Zhang, Ting, Dong, H. Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314533/
https://www.ncbi.nlm.nih.gov/pubmed/25685692
http://dx.doi.org/10.1016/j.molmet.2014.10.005