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Homo-β-amino acid containing MBP(85–99) analogs alleviate experimental autoimmune encephalomyelitis

MBP(85–99), an immuno-dominant epitope of myelin basic protein which binds to the major histocompatibility complex haplotype HLA-DR2 is widely implicated in the pathogenesis of multiple sclerosis. J5, an antagonist of MBP(85–99), that blocks the binding of MBP(85–99) to soluble HLA-DR2b much more ef...

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Detalles Bibliográficos
Autores principales: Kant, Ravi, Pasi, Shweta, Surolia, Avadhesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314633/
https://www.ncbi.nlm.nih.gov/pubmed/25644378
http://dx.doi.org/10.1038/srep08205