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miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells

Human telomerase reverse transcriptase (hTERT) plays a crucial role in cancer development. We previously identified paired-like homeodomain1 (PITX1) as an hTERT suppressor gene. However, the underlying mechanisms that are involved in the regulation of PITX1 remain unknown. Here, we report that the m...

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Detalles Bibliográficos
Autores principales: Ohira, Takahito, Naohiro, Sunamura, Nakayama, Yuji, Osaki, Mitsuhiko, Okada, Futoshi, Oshimura, Mitsuo, Kugoh, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314654/
https://www.ncbi.nlm.nih.gov/pubmed/25643913
http://dx.doi.org/10.1038/srep08201