Identification and X-ray Co-crystal Structure of a Small-Molecule Activator of LFA-1-ICAM-1 Binding**

Stabilization of protein–protein interactions by small molecules is a concept with few examples reported to date. Herein we describe the identification and X-ray co-crystal structure determination of IBE-667, an ICAM-1 binding enhancer for LFA-1. IBE-667 was designed based on the SAR information obt...

Descripción completa

Detalles Bibliográficos
Autores principales: Hintersteiner, Martin, Kallen, Jörg, Schmied, Mario, Graf, Christine, Jung, Thomas, Mudd, Gemma, Shave, Steven, Gstach, Hubert, Auer, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314669/
https://www.ncbi.nlm.nih.gov/pubmed/24692345
http://dx.doi.org/10.1002/anie.201310240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314669/
https://www.ncbi.nlm.nih.gov/pubmed/24692345
http://dx.doi.org/10.1002/anie.201310240

Ejemplares similares