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TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity

Despite overwhelming evidence that transcriptional activation by TP53 is critical for its tumor suppressive activity, the mechanisms by which TP53 engages the genome in the context of chromatin to activate transcription are not well understood. Using a compendium of novel and existing genome-wide da...

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Detalles Bibliográficos
Autores principales: Sammons, Morgan A., Zhu, Jiajun, Drake, Adam M., Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315292/
https://www.ncbi.nlm.nih.gov/pubmed/25391375
http://dx.doi.org/10.1101/gr.181883.114