Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial

The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE) of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrou...

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Detalles Bibliográficos
Autores principales: Edlefsen, Paul T., Rolland, Morgane, Hertz, Tomer, Tovanabutra, Sodsai, Gartland, Andrew J., deCamp, Allan C., Magaret, Craig A., Ahmed, Hasan, Gottardo, Raphael, Juraska, Michal, McCoy, Connor, Larsen, Brendan B., Sanders-Buell, Eric, Carrico, Chris, Menis, Sergey, Bose, Meera, Arroyo, Miguel A., O’Connell, Robert J., Nitayaphan, Sorachai, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, Robb, Merlin L., Kirys, Tatsiana, Georgiev, Ivelin S., Kwong, Peter D., Scheffler, Konrad, Pond, Sergei L. Kosakovsky, Carlson, Jonathan M., Michael, Nelson L., Schief, William R., Mullins, James I., Kim, Jerome H., Gilbert, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315437/
https://www.ncbi.nlm.nih.gov/pubmed/25646817
http://dx.doi.org/10.1371/journal.pcbi.1003973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315437/
https://www.ncbi.nlm.nih.gov/pubmed/25646817
http://dx.doi.org/10.1371/journal.pcbi.1003973

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