Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt

Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis. However, mTORC1 hyperactivity per se does not induce steatosis in mouse livers, but instead, protec...

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Detalles Bibliográficos
Autores principales: Kenerson, Heidi L., Subramanian, Savitha, McIntyre, Rebecca, Kazami, Machiko, Yeung, Raymond S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315590/
https://www.ncbi.nlm.nih.gov/pubmed/25646773
http://dx.doi.org/10.1371/journal.pone.0117000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315590/
https://www.ncbi.nlm.nih.gov/pubmed/25646773
http://dx.doi.org/10.1371/journal.pone.0117000

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