Cargando…

Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt

Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis. However, mTORC1 hyperactivity per se does not induce steatosis in mouse livers, but instead, protec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kenerson, Heidi L., Subramanian, Savitha, McIntyre, Rebecca, Kazami, Machiko, Yeung, Raymond S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315590/ https://www.ncbi.nlm.nih.gov/pubmed/25646773 http://dx.doi.org/10.1371/journal.pone.0117000

Ejemplares similares

Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency
por: McIntyre, Rebecca L, et al.
Publicado: (2015)

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
por: Kim, KyeongJin, et al.
Publicado: (2016)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis
por: Ren, Qian‐Nan, et al.
Publicado: (2021)

TFEB-mTORC1 feedback loop in metabolism and cancer
por: Di Malta, Chiara, et al.
Publicado: (2017)

High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis
por: Gayatri, Meher Bolisetti, et al.
Publicado: (2022)

Transient activation of mTORC1 signaling in skeletal muscle is independent of Akt1 regulation
por: Miyazaki, Mitsunori, et al.
Publicado: (2020)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
por: Salazar, María, et al.
Publicado: (2015)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
por: Murai, Atsuko, et al.
Publicado: (2012)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling
por: Xu, Ke, et al.
Publicado: (2017)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation
por: Chung, Chih-Yao, et al.
Publicado: (2021)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-κB or Akt/mTORC1
por: Arfianti, Evi, et al.
Publicado: (2016)

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
por: Palmieri, Michela, et al.
Publicado: (2017)

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells
por: Joha, S, et al.
Publicado: (2012)

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
por: Humphrey, Sean J., et al.
Publicado: (2013)

Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation.
por: Balcazar Morales, Norman, et al.
Publicado: (2012)

SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt
por: Meng, Haitao, et al.
Publicado: (2013)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma
por: Holmes, Brent, et al.
Publicado: (2017)

Corrigendum: mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
por: Palmieri, Michela, et al.
Publicado: (2017)

mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity
por: Kalim, Khalid W., et al.
Publicado: (2017)

Multiple lines of inhibitory feedback on AKT kinase in Schwann cells lacking TSC1/2 hint at distinct functions of mTORC1 and AKT in nerve development
por: Wong, Keit Men, et al.
Publicado: (2018)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer
por: Yang, Wei, et al.
Publicado: (2018)

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
por: Porstmann, Thomas, et al.
Publicado: (2008)

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
por: Zhang, Hui H., et al.
Publicado: (2009)

Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
por: Ronellenfitsch, Michael W., et al.
Publicado: (2018)

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis
por: Martinez, Nuria, et al.
Publicado: (2019)

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
por: Zhou, Xin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gf2gnus8s1nq98a6u6llc7t964