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Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I

Respiratory complex I inhibition by drugs and other chemicals has been implicated as a frequent mode of mitochondria-mediated cell injury. However, the exact mechanisms leading to the activation of cell death pathways are incompletely understood. This study was designed to explore the relative contr...

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Detalles Bibliográficos
Autores principales: Imaizumi, Naoki, Kwang Lee, Kang, Zhang, Carmen, Boelsterli, Urs A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315936/
https://www.ncbi.nlm.nih.gov/pubmed/25625582
http://dx.doi.org/10.1016/j.redox.2015.01.005