Cargando…

Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I

Respiratory complex I inhibition by drugs and other chemicals has been implicated as a frequent mode of mitochondria-mediated cell injury. However, the exact mechanisms leading to the activation of cell death pathways are incompletely understood. This study was designed to explore the relative contr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Imaizumi, Naoki, Kwang Lee, Kang, Zhang, Carmen, Boelsterli, Urs A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315936/ https://www.ncbi.nlm.nih.gov/pubmed/25625582 http://dx.doi.org/10.1016/j.redox.2015.01.005

Ejemplares similares

Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes
por: Lee, Kang Kwang, et al.
Publicado: (2014)

Stem Cell Strategies to Evaluate Idiosyncratic Drug-induced Liver Injury
por: Krueger, Winfried, et al.
Publicado: (2014)

Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells
por: Soustek, Meghan S., et al.
Publicado: (2018)

Mitochondrial complex I inhibition as a possible mechanism of chlorpyrifos induced neurotoxicity
por: Salama, Mohamed, et al.
Publicado: (2014)

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
por: Terron, Andrea, et al.
Publicado: (2017)

Preventing cell death with a ‘check valve' in mitochondrial complex I?
por: Fontaine, E, et al.
Publicado: (2016)

Mitochondrial Complex I Inhibition Accelerates Amyloid Toxicity
por: Joh, Yechan, et al.
Publicado: (2017)

Metformin Inhibits Mitochondrial Complex I To Promote Health
por: Chandel, Navdeep
Publicado: (2021)

Deactivation blocks proton pathways in the mitochondrial complex I
por: Röpke, Michael, et al.
Publicado: (2021)

Integrative Toxicoproteomics Implicates Impaired Mitochondrial Glutathione Import as an Off-Target Effect of Troglitazone
por: Lee, Yie Hou, et al.
Publicado: (2013)

Mitochondrial complex I and cell death: a semi-automatic shotgun model
por: Gonzalez-Halphen, D, et al.
Publicado: (2011)

Water-Soluble Coenzyme Q10 Inhibits Nuclear Translocation of Apoptosis Inducing Factor and Cell Death Caused by Mitochondrial Complex I Inhibition
por: Li, Haining, et al.
Publicado: (2014)

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
por: Balsa, Eduardo, et al.
Publicado: (2020)

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
por: Wheaton, William W, et al.
Publicado: (2014)

Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences
por: Fontaine, Eric
Publicado: (2018)

Mitochondrial Complex I Inhibitors and Forced Oxidative Phosphorylation Synergize in Inducing Cancer Cell Death
por: Palorini, Roberta, et al.
Publicado: (2013)

Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition
por: Maharjan, Sunita, et al.
Publicado: (2014)

Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation
por: Hou, Wo‐Lin, et al.
Publicado: (2017)

Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I
por: Ling, Sunbin, et al.
Publicado: (2017)

Novel mitochondrial complex I-inhibiting peptides restrain NADH dehydrogenase activity
por: Xue, Yao-Peng, et al.
Publicado: (2019)

Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat Cells
por: Lambert, Jonathan R. A., et al.
Publicado: (2019)

Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited
por: Pallag, Gergely, et al.
Publicado: (2022)

Death Receptor Interactions With the Mitochondrial Cell Death Pathway During Immune Cell-, Drug- and Toxin-Induced Liver Damage
por: Spinnenhirn, Valentina, et al.
Publicado: (2019)

Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death
por: Skommer, Joanna, et al.
Publicado: (2010)

Molecular mechanism and physiological role of active–deactive transition of mitochondrial complex I
por: Babot, Marion, et al.
Publicado: (2013)

Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
por: Galemou Yoga, Etienne, et al.
Publicado: (2020)

The Mitochondrial Complex(I)ty of Cancer
por: Urra, Félix A., et al.
Publicado: (2017)

Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I
por: Thomas, Nicholas O., et al.
Publicado: (2019)

Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I
por: Grba, Daniel N., et al.
Publicado: (2022)

Mitochondrial Complex I, a Possible Sensible Site of cAMP Pathway in Aging
por: Signorile, Anna, et al.
Publicado: (2023)

Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases
por: Martin, Lee J.
Publicado: (2010)

High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism
por: Parey, Kristian, et al.
Publicado: (2021)

Targeting Mitochondrial Cell Death Pathway to Overcome Drug Resistance with a Newly Developed Iron Chelate
por: Ganguly, Avishek, et al.
Publicado: (2010)

BID links ferroptosis to mitochondrial cell death pathways
por: Neitemeier, Sandra, et al.
Publicado: (2017)

Coenzyme Q10 Ameliorates Ultraviolet B Irradiation Induced Cell Death Through Inhibition of Mitochondrial Intrinsic Cell Death Pathway
por: Jing, Li, et al.
Publicado: (2011)

Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis
por: Heishima, Kazuki, et al.
Publicado: (2021)

Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver
por: Yu, Muyu, et al.
Publicado: (2021)

Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes
por: Ziabreva, Iryna, et al.
Publicado: (2010)

Combinatorial Therapeutic Effect of Inhibitors of Aldehyde Dehydrogenase and Mitochondrial Complex I, and the Chemotherapeutic Drug, Temozolomide against Glioblastoma Tumorspheres
por: Park, Hun Ho, et al.
Publicado: (2021)

Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses
por: Lin, Longfei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8jgspf9b66eomhhi994jcdk5nm