Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration

While islet amyloid polypeptide (IAPP) aggregation is associated with β-cell death in type-II diabetes (T2D), environmental elements of β-cell granules — e.g. high concentrations of insulin and Zn(2+) — inhibit IAPP aggregation in healthy individuals. The inhibition by insulin is experimentally know...

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Detalles Bibliográficos
Autores principales: Nedumpully-Govindan, Praveen, Ding, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316164/
https://www.ncbi.nlm.nih.gov/pubmed/25649462
http://dx.doi.org/10.1038/srep08240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316164/
https://www.ncbi.nlm.nih.gov/pubmed/25649462
http://dx.doi.org/10.1038/srep08240

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