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Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration
While islet amyloid polypeptide (IAPP) aggregation is associated with β-cell death in type-II diabetes (T2D), environmental elements of β-cell granules — e.g. high concentrations of insulin and Zn(2+) — inhibit IAPP aggregation in healthy individuals. The inhibition by insulin is experimentally know...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316164/ https://www.ncbi.nlm.nih.gov/pubmed/25649462 http://dx.doi.org/10.1038/srep08240 |