Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila

Camptothecin (CPT) belongs to a group of monoterpenoidindole alkaloids (TIAs) and its derivatives such as irinothecan and topothecan have been widely used worldwide for the treatment of cancer, giving rise to rapidly increasing market demands. Genes from Catharanthus roseus encoding strictosidine sy...

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Detalles Bibliográficos
Autores principales: Cui, Lijie, Ni, Xiaoling, Ji, Qian, Teng, Xiaojuan, Yang, Yanru, Wu, Chao, Zekria, David, Zhang, Dasheng, Kai, Guoyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316170/
https://www.ncbi.nlm.nih.gov/pubmed/25648209
http://dx.doi.org/10.1038/srep08227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316170/
https://www.ncbi.nlm.nih.gov/pubmed/25648209
http://dx.doi.org/10.1038/srep08227

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