Chronic stimulation of alpha-2A-adrenoceptors with guanfacine protects rodent prefrontal cortex dendritic spines and cognition from the effects of chronic stress

The prefrontal cortex (PFC) provides top-down regulation of behavior, cognition, and emotion, including spatial working memory. However, these PFC abilities are greatly impaired by exposure to acute or chronic stress. Chronic stress exposure in rats induces atrophy of PFC dendrites and spines that c...

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Detalles Bibliográficos
Autores principales: Hains, Avis Brennan, Yabe, Yoko, Arnsten, Amy F.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316374/
https://www.ncbi.nlm.nih.gov/pubmed/25664335
http://dx.doi.org/10.1016/j.ynstr.2015.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316374/
https://www.ncbi.nlm.nih.gov/pubmed/25664335
http://dx.doi.org/10.1016/j.ynstr.2015.01.001

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