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Impacts of Activation of the Mitogen-Activated Protein Kinase Pathway in Pancreatic Cancer

Pancreatic cancer is characterized by constitutive activation of the mitogen-activated protein kinase (MAPK) pathway. Mutations of KRAS or BRAF and epigenetic abrogation of DUSP6 contribute synergistically to the constitutive activation of MAPK. Active MAPK induces the expression of a variety of gen...

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Detalles Bibliográficos
Autor principal:	Furukawa, Toru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316689/ https://www.ncbi.nlm.nih.gov/pubmed/25699241 http://dx.doi.org/10.3389/fonc.2015.00023

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