Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells

BACKGROUND: Gene amplification is a frequent manifestation of genomic instability that plays a role in tumour progression and development of drug resistance. It is manifested cytogenetically as extrachromosomal double minutes (DMs) or intrachromosomal homogeneously staining regions (HSRs). To better...

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Detalles Bibliográficos
Autores principales: Meng, Xiangning, Qi, Xiuying, Guo, Huanhuan, Cai, Mengdi, Li, Chunxiang, Zhu, Jing, Chen, Feng, Guo, Huan, Li, Jie, Zhao, Yuzhen, Liu, Peng, Jia, Xueyuan, Yu, Jingcui, Zhang, Chunyu, Sun, Wenjing, Yu, Yang, Jin, Yan, Bai, Jing, Wang, Mingrong, Rosales, Jesusa, Lee, Ki-Young, Fu, Songbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Cancer Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316941/
https://www.ncbi.nlm.nih.gov/pubmed/25537274
http://dx.doi.org/10.1136/jmedgenet-2014-102703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316941/
https://www.ncbi.nlm.nih.gov/pubmed/25537274
http://dx.doi.org/10.1136/jmedgenet-2014-102703

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