U2AF1 mutations alter splice site recognition in hematological malignancies

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3′ splice site recognition factor U2AF1 alter its normal role in RNA splicing. We...

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Detalles Bibliográficos
Autores principales: Ilagan, Janine O., Ramakrishnan, Aravind, Hayes, Brian, Murphy, Michele E., Zebari, Ahmad S., Bradley, Philip, Bradley, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317169/
https://www.ncbi.nlm.nih.gov/pubmed/25267526
http://dx.doi.org/10.1101/gr.181016.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317169/
https://www.ncbi.nlm.nih.gov/pubmed/25267526
http://dx.doi.org/10.1101/gr.181016.114

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