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Functional desensitization of the β(2) adrenoceptor is not dependent on agonist efficacy

Chronic treatment with β(2) adrenoceptor agonists is recommended as a first-line maintenance therapy for chronic obstructive pulmonary disease (COPD). However, a potential consequence of long-term treatment may be the loss of functional response (tachyphylaxis) over time. In this study, we have inve...

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Detalles Bibliográficos
Autores principales: Rosethorne, Elizabeth M, Bradley, Michelle E, Kent, Toby C, Charlton, Steven J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317232/
https://www.ncbi.nlm.nih.gov/pubmed/25692019
http://dx.doi.org/10.1002/prp2.101