Development of sequence-specific antimicrobials based on programmable CRISPR-Cas nucleases

Antibiotics target conserved bacterial cellular pathways or growth functions and therefore cannot selectively kill specific members of a complex microbial population. Here, we develop programmable, sequence-specific antimicrobials using the RNA-guided nuclease Cas9(1, 2) delivered by a bacteriophage...

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Bibliographic Details
Main Authors: Bikard, David, Euler, Chad, Jiang, Wenyan, Nussenzweig, Philip M., Goldberg, Gregory W., Duportet, Xavier, Fischetti, Vincent A., Marraffini, Luciano A.
Format: Online Article Text
Language:English
Published: 2014
Subjects:
Article
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317352/
https://www.ncbi.nlm.nih.gov/pubmed/25282355
http://dx.doi.org/10.1038/nbt.3043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317352/
https://www.ncbi.nlm.nih.gov/pubmed/25282355
http://dx.doi.org/10.1038/nbt.3043

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