Comparison of gene expression patterns across twelve tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects

Transcriptional profile based subtypes of cancer are often viewed as identifying different diseases from the same tissue origin. Understanding the mechanisms driving the subtypes may be key in development of novel therapeutics but is challenged by lineage-specific expression signals. Using a t-test...

Descripción completa

Detalles Bibliográficos
Autores principales: Martínez, Emmanuel, Yoshihara, Kosuke, Kim, Hoon, Mills, Gordon M., Treviño, Victor, Verhaak, Roel GW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317393/
https://www.ncbi.nlm.nih.gov/pubmed/25088195
http://dx.doi.org/10.1038/onc.2014.216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317393/
https://www.ncbi.nlm.nih.gov/pubmed/25088195
http://dx.doi.org/10.1038/onc.2014.216

Ejemplares similares