Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear. Here, we show that reduced levels of the conserved RNA methyltransferase NSUN5 increase the...

Descripción completa

Detalles Bibliográficos
Autores principales: Schosserer, Markus, Minois, Nadege, Angerer, Tina B., Amring, Manuela, Dellago, Hanna, Harreither, Eva, Calle-Perez, Alfonso, Pircher, Andreas, Gerstl, Matthias Peter, Pfeifenberger, Sigrid, Brandl, Clemens, Sonntagbauer, Markus, Kriegner, Albert, Linder, Angela, Weinhäusel, Andreas, Mohr, Thomas, Steiger, Matthias, Mattanovich, Diethard, Rinnerthaler, Mark, Karl, Thomas, Sharma, Sunny, Entian, Karl-Dieter, Kos, Martin, Breitenbach, Michael, Wilson, Iain B.H., Polacek, Norbert, Grillari-Voglauer, Regina, Breitenbach-Koller, Lore, Grillari, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317494/
https://www.ncbi.nlm.nih.gov/pubmed/25635753
http://dx.doi.org/10.1038/ncomms7158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317494/
https://www.ncbi.nlm.nih.gov/pubmed/25635753
http://dx.doi.org/10.1038/ncomms7158

Ejemplares similares