Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, regulates the self-renewal ability and pluripotency of ESCs. B...

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Detalles Bibliográficos
Autores principales: Micco, Raffaella Di, Fontanals-Cirera, Barbara, Low, Vivien, Ntziachristos, Panagiotis, Yuen, Stephanie K., Lovell, Claudia D., Dolgalev, Igor, Yonekubo, Yoshiya, Zhang, Guangtao, Rusinova, Elena, Gerona-Navarro, Guillermo, Cañamero, Marta, Ohlmeyer, Michael, Aifantis, Iannis, Zhou, Ming-Ming, Tsirigos, Aristotelis, Hernando, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317728/
https://www.ncbi.nlm.nih.gov/pubmed/25263550
http://dx.doi.org/10.1016/j.celrep.2014.08.055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317728/
https://www.ncbi.nlm.nih.gov/pubmed/25263550
http://dx.doi.org/10.1016/j.celrep.2014.08.055

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