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Targeting DNA damage response in cancer therapy

Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing DNA damage. DNA damage is normally recognized and repaired by the intrinsic DNA damage response machinery. If the damaged lesions are successfully repaired, the cells will survive. In order to specifically and...

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Detalles Bibliográficos
Autores principales: Hosoya, Noriko, Miyagawa, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317796/
https://www.ncbi.nlm.nih.gov/pubmed/24484288
http://dx.doi.org/10.1111/cas.12366