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Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia

Bone metastasis is a multistep process that includes cancer cell dissemination, colonization, and metastatic growth. Furthermore, this process involves complex, reciprocal interactions between cancer cells and the bone microenvironment. Bone resorption is known to be involved in both osteolytic and...

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Detalles Bibliográficos
Autores principales: Kuchimaru, Takahiro, Hoshino, Takuya, Aikawa, Tomoya, Yasuda, Hisataka, Kobayashi, Tatsuya, Kadonosono, Tetsuya, Kizaka-Kondoh, Shinae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317828/
https://www.ncbi.nlm.nih.gov/pubmed/24597654
http://dx.doi.org/10.1111/cas.12391