Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16

Leukemia stem cells (LSC) are resistant to conventional chemotherapy and persistent LSC after chemotherapy are supposed to be a major cause of relapse. However, information on genetic or epigenetic regulation of stem cell properties is still limited and LSC-targeted drugs have scarcely been identifi...

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Detalles Bibliográficos
Autores principales: Ueda, Koki, Yoshimi, Akihide, Kagoya, Yuki, Nishikawa, Satoshi, Marquez, Victor E, Nakagawa, Masahiro, Kurokawa, Mineo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317832/
https://www.ncbi.nlm.nih.gov/pubmed/24612037
http://dx.doi.org/10.1111/cas.12386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317832/
https://www.ncbi.nlm.nih.gov/pubmed/24612037
http://dx.doi.org/10.1111/cas.12386

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