Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway

Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by tumor cells is a major roadblock. We investigated whether quercetin, a flavonoid, can sensitize human ovarian cancer cells to TRAIL. Results...

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Detalles Bibliográficos
Autores principales: Yi, Liu, Zongyuan, Yang, Cheng, Gong, Lingyun, Zhang, GuiLian, Yu, Wei, Gong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317845/
https://www.ncbi.nlm.nih.gov/pubmed/24612139
http://dx.doi.org/10.1111/cas.12395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317845/
https://www.ncbi.nlm.nih.gov/pubmed/24612139
http://dx.doi.org/10.1111/cas.12395

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