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Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells

Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is treated with HER2-targeted agents, such as trastuzumab and lapatinib, that suppress signaling by phosphatidylinositol 3-kinase (PI3K)-Akt and MAPK pathways. However, resistance to HER2-targeted therapy remains a major clinical...

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Detalles Bibliográficos
Autores principales: Hosonaga, Mari, Arima, Yoshimi, Sugihara, Eiji, Kohno, Norio, Saya, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317915/
https://www.ncbi.nlm.nih.gov/pubmed/24754246
http://dx.doi.org/10.1111/cas.12427