Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1

Helicobacter pylori strains carrying the cagA gene are associated with severe disease outcomes, most notably gastric cancer. CagA protein is delivered into gastric epithelial cells by a type IV secretion system. The translocated CagA undergoes tyrosine phosphorylation at the C-terminal EPIYA motifs...

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Detalles Bibliográficos
Autores principales: Hashi, Kana, Murata-Kamiya, Naoko, Varon, Christine, Mégraud, Francis, Dominguez-Bello, Maria Gloria, Hatakeyama, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317943/
https://www.ncbi.nlm.nih.gov/pubmed/24354359
http://dx.doi.org/10.1111/cas.12342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317943/
https://www.ncbi.nlm.nih.gov/pubmed/24354359
http://dx.doi.org/10.1111/cas.12342

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