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Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions
Dicentric chromosomes are unstable products of erroneous DNA repair events that can lead to further genome rearrangements and extended gene copy number variations. During mitosis, they form anaphase bridges, resulting in chromosome breakage by an unknown mechanism. In budding yeast, dicentrics gener...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318148/ https://www.ncbi.nlm.nih.gov/pubmed/25644606 http://dx.doi.org/10.1101/gad.254664.114 |