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Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups
BACKGROUND: PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318154/ https://www.ncbi.nlm.nih.gov/pubmed/25613750 http://dx.doi.org/10.1186/s12885-015-1011-9 |