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Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

BACKGROUND: PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation....

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Detalles Bibliográficos
Autores principales:	Bond, Catherine E, Bettington, Mark L, Pearson, Sally-Ann, McKeone, Diane M, Leggett, Barbara A, Whitehall, Vicki LJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318154/ https://www.ncbi.nlm.nih.gov/pubmed/25613750 http://dx.doi.org/10.1186/s12885-015-1011-9

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