Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities

BACKGROUND: Dobesilate (2,5-dihydroxyphenyl sulfonate, DHPS) was recently identified as the most potent member of a family of fibroblast growth factor (FGF) inhibitors headed by gentisic acid, one of the main catabolites of aspirin. Although FGFs were first described as inducers of angiogenesis, the...

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Detalles Bibliográficos
Autores principales: Angulo, Javier, Cuevas, Pedro, Cuevas, Begoña, El Youssef, Mohammad, Fernández, Argentina, Martínez-Salamanca, Eduardo, González-Corrochano, Rocío, Giménez-Gallego, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318172/
https://www.ncbi.nlm.nih.gov/pubmed/25638171
http://dx.doi.org/10.1186/s12967-015-0413-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318172/
https://www.ncbi.nlm.nih.gov/pubmed/25638171
http://dx.doi.org/10.1186/s12967-015-0413-4

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