Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities

BACKGROUND: Dobesilate (2,5-dihydroxyphenyl sulfonate, DHPS) was recently identified as the most potent member of a family of fibroblast growth factor (FGF) inhibitors headed by gentisic acid, one of the main catabolites of aspirin. Although FGFs were first described as inducers of angiogenesis, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Angulo, Javier, Cuevas, Pedro, Cuevas, Begoña, El Youssef, Mohammad, Fernández, Argentina, Martínez-Salamanca, Eduardo, González-Corrochano, Rocío, Giménez-Gallego, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318172/
https://www.ncbi.nlm.nih.gov/pubmed/25638171
http://dx.doi.org/10.1186/s12967-015-0413-4

Ejemplares similares

Ejemplares similares