IgG4-related kidney disease – an update

PURPOSE OF REVIEW: IgG4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disorder that can affect most organs/tissues such as sarcoidosis. The kidney is a frequently affected organ with tubulointerstitial nephritis (TIN), the representative lesion of IgG4-RD. This review focu...

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Autores principales: Kawano, Mitsuhiro, Saeki, Takako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318645/
https://www.ncbi.nlm.nih.gov/pubmed/25594543
http://dx.doi.org/10.1097/MNH.0000000000000102
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author Kawano, Mitsuhiro
Saeki, Takako
author_facet Kawano, Mitsuhiro
Saeki, Takako
author_sort Kawano, Mitsuhiro
collection PubMed
description PURPOSE OF REVIEW: IgG4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disorder that can affect most organs/tissues such as sarcoidosis. The kidney is a frequently affected organ with tubulointerstitial nephritis (TIN), the representative lesion of IgG4-RD. This review focuses on the latest knowledge of IgG4-related kidney disease (IgG4-RKD). RECENT FINDINGS: A wide range of renal manifestations of IgG4-RD, that is TIN, membranous glomerulonephritis (MGN) and other glomerular lesions, and pyelitis, are collectively referred to as IgG4-RKD. Clinically, decreased renal function, or characteristic imaging findings such as multiple low-density lesions on contrast-enhanced computed tomography or diffuse thickening of the renal pelvic wall, are typical presenting features. Although a rapid response to corticosteroid therapy is a very important feature of IgG4-TIN, in cases in which renal function is moderately to severely decreased before therapy, only partial recovery of renal function is obtained. SUMMARY: TIN with characteristic imaging findings is a typical manifestation of IgG4-RKD in the interstitium, while MGN is a representative manifestation of the glomerular lesions. Although IgG4 is a central feature of IgG4-RD, the recent discovery of IgG4-negative IgG4-RD raises questions about the causative role of the IgG4 molecule in this context.
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spelling pubmed-43186452015-02-17 IgG4-related kidney disease – an update Kawano, Mitsuhiro Saeki, Takako Curr Opin Nephrol Hypertens CLINICAL NEPHROLOGY: Edited by Bradley M. Denker PURPOSE OF REVIEW: IgG4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disorder that can affect most organs/tissues such as sarcoidosis. The kidney is a frequently affected organ with tubulointerstitial nephritis (TIN), the representative lesion of IgG4-RD. This review focuses on the latest knowledge of IgG4-related kidney disease (IgG4-RKD). RECENT FINDINGS: A wide range of renal manifestations of IgG4-RD, that is TIN, membranous glomerulonephritis (MGN) and other glomerular lesions, and pyelitis, are collectively referred to as IgG4-RKD. Clinically, decreased renal function, or characteristic imaging findings such as multiple low-density lesions on contrast-enhanced computed tomography or diffuse thickening of the renal pelvic wall, are typical presenting features. Although a rapid response to corticosteroid therapy is a very important feature of IgG4-TIN, in cases in which renal function is moderately to severely decreased before therapy, only partial recovery of renal function is obtained. SUMMARY: TIN with characteristic imaging findings is a typical manifestation of IgG4-RKD in the interstitium, while MGN is a representative manifestation of the glomerular lesions. Although IgG4 is a central feature of IgG4-RD, the recent discovery of IgG4-negative IgG4-RD raises questions about the causative role of the IgG4 molecule in this context. Lippincott Williams & Wilkins 2015-03 2015-02-11 /pmc/articles/PMC4318645/ /pubmed/25594543 http://dx.doi.org/10.1097/MNH.0000000000000102 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by/4.0
spellingShingle CLINICAL NEPHROLOGY: Edited by Bradley M. Denker
Kawano, Mitsuhiro
Saeki, Takako
IgG4-related kidney disease – an update
title IgG4-related kidney disease – an update
title_full IgG4-related kidney disease – an update
title_fullStr IgG4-related kidney disease – an update
title_full_unstemmed IgG4-related kidney disease – an update
title_short IgG4-related kidney disease – an update
title_sort igg4-related kidney disease – an update
topic CLINICAL NEPHROLOGY: Edited by Bradley M. Denker
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318645/
https://www.ncbi.nlm.nih.gov/pubmed/25594543
http://dx.doi.org/10.1097/MNH.0000000000000102
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