IgG4-related kidney disease – an update
PURPOSE OF REVIEW: IgG4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disorder that can affect most organs/tissues such as sarcoidosis. The kidney is a frequently affected organ with tubulointerstitial nephritis (TIN), the representative lesion of IgG4-RD. This review focu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318645/ https://www.ncbi.nlm.nih.gov/pubmed/25594543 http://dx.doi.org/10.1097/MNH.0000000000000102 |
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author | Kawano, Mitsuhiro Saeki, Takako |
author_facet | Kawano, Mitsuhiro Saeki, Takako |
author_sort | Kawano, Mitsuhiro |
collection | PubMed |
description | PURPOSE OF REVIEW: IgG4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disorder that can affect most organs/tissues such as sarcoidosis. The kidney is a frequently affected organ with tubulointerstitial nephritis (TIN), the representative lesion of IgG4-RD. This review focuses on the latest knowledge of IgG4-related kidney disease (IgG4-RKD). RECENT FINDINGS: A wide range of renal manifestations of IgG4-RD, that is TIN, membranous glomerulonephritis (MGN) and other glomerular lesions, and pyelitis, are collectively referred to as IgG4-RKD. Clinically, decreased renal function, or characteristic imaging findings such as multiple low-density lesions on contrast-enhanced computed tomography or diffuse thickening of the renal pelvic wall, are typical presenting features. Although a rapid response to corticosteroid therapy is a very important feature of IgG4-TIN, in cases in which renal function is moderately to severely decreased before therapy, only partial recovery of renal function is obtained. SUMMARY: TIN with characteristic imaging findings is a typical manifestation of IgG4-RKD in the interstitium, while MGN is a representative manifestation of the glomerular lesions. Although IgG4 is a central feature of IgG4-RD, the recent discovery of IgG4-negative IgG4-RD raises questions about the causative role of the IgG4 molecule in this context. |
format | Online Article Text |
id | pubmed-4318645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-43186452015-02-17 IgG4-related kidney disease – an update Kawano, Mitsuhiro Saeki, Takako Curr Opin Nephrol Hypertens CLINICAL NEPHROLOGY: Edited by Bradley M. Denker PURPOSE OF REVIEW: IgG4-related disease (IgG4-RD) is a recently recognized systemic inflammatory disorder that can affect most organs/tissues such as sarcoidosis. The kidney is a frequently affected organ with tubulointerstitial nephritis (TIN), the representative lesion of IgG4-RD. This review focuses on the latest knowledge of IgG4-related kidney disease (IgG4-RKD). RECENT FINDINGS: A wide range of renal manifestations of IgG4-RD, that is TIN, membranous glomerulonephritis (MGN) and other glomerular lesions, and pyelitis, are collectively referred to as IgG4-RKD. Clinically, decreased renal function, or characteristic imaging findings such as multiple low-density lesions on contrast-enhanced computed tomography or diffuse thickening of the renal pelvic wall, are typical presenting features. Although a rapid response to corticosteroid therapy is a very important feature of IgG4-TIN, in cases in which renal function is moderately to severely decreased before therapy, only partial recovery of renal function is obtained. SUMMARY: TIN with characteristic imaging findings is a typical manifestation of IgG4-RKD in the interstitium, while MGN is a representative manifestation of the glomerular lesions. Although IgG4 is a central feature of IgG4-RD, the recent discovery of IgG4-negative IgG4-RD raises questions about the causative role of the IgG4 molecule in this context. Lippincott Williams & Wilkins 2015-03 2015-02-11 /pmc/articles/PMC4318645/ /pubmed/25594543 http://dx.doi.org/10.1097/MNH.0000000000000102 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | CLINICAL NEPHROLOGY: Edited by Bradley M. Denker Kawano, Mitsuhiro Saeki, Takako IgG4-related kidney disease – an update |
title | IgG4-related kidney disease – an update |
title_full | IgG4-related kidney disease – an update |
title_fullStr | IgG4-related kidney disease – an update |
title_full_unstemmed | IgG4-related kidney disease – an update |
title_short | IgG4-related kidney disease – an update |
title_sort | igg4-related kidney disease – an update |
topic | CLINICAL NEPHROLOGY: Edited by Bradley M. Denker |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318645/ https://www.ncbi.nlm.nih.gov/pubmed/25594543 http://dx.doi.org/10.1097/MNH.0000000000000102 |
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