Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells

Disulfiram, a clinically used alcohol-deterrent has gained prominence as a potential anti-cancer agent due to its impact on copper-dependent processes. Few studies have investigated zinc effects on disulfiram action, despite it having high affinity for this metal. Here we studied the cytotoxic effec...

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Detalles Bibliográficos
Autores principales: Wiggins, Helen L., Wymant, Jennifer M., Solfa, Francesca, Hiscox, Stephen E., Taylor, Kathryn M., Westwell, Andrew D., Jones, Arwyn T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318799/
https://www.ncbi.nlm.nih.gov/pubmed/25557293
http://dx.doi.org/10.1016/j.bcp.2014.12.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318799/
https://www.ncbi.nlm.nih.gov/pubmed/25557293
http://dx.doi.org/10.1016/j.bcp.2014.12.014

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