Safety and Immunogenicity of DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild-Type Glycoproteins in a Phase I Clinical Trial

BACKGROUND: Ebolavirus and Marburgvirus cause severe hemorrhagic fever with high mortality and are potential bioterrorism agents. There are no available vaccines or therapeutic agents. Previous clinical trials evaluated transmembrane-deleted and point-mutation Ebolavirus glycoproteins (GPs) in candi...

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Detalles Bibliográficos
Autores principales: Sarwar, Uzma N., Costner, Pamela, Enama, Mary E., Berkowitz, Nina, Hu, Zonghui, Hendel, Cynthia S., Sitar, Sandra, Plummer, Sarah, Mulangu, Sabue, Bailer, Robert T., Koup, Richard A., Mascola, John R., Nabel, Gary J., Sullivan, Nancy J., Graham, Barney S., Ledgerwood, Julie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318920/
https://www.ncbi.nlm.nih.gov/pubmed/25225676
http://dx.doi.org/10.1093/infdis/jiu511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318920/
https://www.ncbi.nlm.nih.gov/pubmed/25225676
http://dx.doi.org/10.1093/infdis/jiu511

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