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Embryonic Stem Cell Specific “Master” Replication Origins at the Heart of the Loss of Pluripotency
Epigenetic regulation of the replication program during mammalian cell differentiation remains poorly understood. We performed an integrative analysis of eleven genome-wide epigenetic profiles at 100 kb resolution of Mean Replication Timing (MRT) data in six human cell lines. Compared to the organiz...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319821/ https://www.ncbi.nlm.nih.gov/pubmed/25658386 http://dx.doi.org/10.1371/journal.pcbi.1003969 |