Crystal Structure of Human Importin-α1 (Rch1), Revealing a Potential Autoinhibition Mode Involving Homodimerization

In this study, we determined the crystal structure of N-terminal importin-β-binding domain (IBB)-truncated human importin-α1 (ΔIBB-h-importin-α1) at 2.63 Å resolution. The crystal structure of ΔIBB-h-importin-α1 reveals a novel closed homodimer. The homodimer exists in an autoinhibited state in whic...

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Detalles Bibliográficos
Autores principales: Miyatake, Hideyuki, Sanjoh, Akira, Unzai, Satoru, Matsuda, Go, Tatsumi, Yuko, Miyamoto, Yoichi, Dohmae, Naoshi, Aida, Yoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319847/
https://www.ncbi.nlm.nih.gov/pubmed/25658636
http://dx.doi.org/10.1371/journal.pone.0115995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319847/
https://www.ncbi.nlm.nih.gov/pubmed/25658636
http://dx.doi.org/10.1371/journal.pone.0115995

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